Bromoacylpolystyrene, a New Type of Polymer Support for Solid Phase Peptide Synthesis

Advancements in polymer resins for solid - phase peptide synthesis

The use of polymeric supports in solid-phase peptide synthesis has allowed for the facile, rapid synthesis of short peptides in a one bead/one sequence manner. This approach allows for screening peptide libraries for binding and catalytic activities. Once hits are found, the sequence of the active protein can be determined via mass spectrometry. However, problems arise when trying to create lar...

Solid Phase Peptide Synthesis by Four Component Condensation: Peptide Formation on an Isocyano Polymer Support

The feasibility of peptide synthesis by four component condensation (4CC) [1] has been demonstrated [2]. In particular the advantages of peptide synthesis by 4CC, namely coupling without carboxyl activation, the possibility of reaction in highly polar media, and the effectively unimolecular nature of the coupling step in such coupling of peptide fragments are being recognized [3]. The unique fe...

Solid-phase ATRP synthesis of peptide-polymer hybrids.

A versatile methodology to prepare hybrid biomaterials by atom transfer radical polymerization from resin-supported peptides has been established. As an example, we have synthesized a GRGDS-functionalized poly(2-hydroxyethyl methacrylate). The peptide-polymer was characterized by solid-state (13)C NMR and GPC and found to have a number average molecular weight of 4420 and a polydispersity of 1....

Solvents for solid-phase peptide synthesis.

synthesis of molecularly imprinted polymer as a solid phase sorbent for pesticide dursban

this study describes the synthesis of molecularly imprinted polymers (mips) by using an anti-che ops, namely dursban, as a template. non-covalent bulk polymerization was successfully applied to synthesis different imprinted and non-imprinted polymers with maa, mma, aa, and 4-vpy as monomer in selected porogens (chloroform, toluene, and acetonitrile). in order to evaluate the template binding of...